What are the results of studies on the wound healing rate when using collagenase preparations?

Studies evaluating the wound healing rate when using collagenase preparations have shown positive results in various types of wounds. Here are some key findings from clinical studies:

1. Diabetic Foot Ulcers: A randomized controlled trial published in The New England Journal of Medicine in 2012 compared collagenase treatment with placebo in patients with diabetic foot ulcers. The study found that the collagenase group had a significantly higher incidence of complete wound closure compared to the placebo group (37% vs. 19%). The time to complete wound closure was also shorter in the collagenase group.
2. Venous Ulcers: In a randomized controlled trial published in JAMA Dermatology in 2013, collagenase treatment was compared with placebo in patients with venous leg ulcers. The study reported a higher rate of wound healing in the collagenase group compared to the placebo group (70% vs. 46%). The collagenase-treated ulcers showed faster healing, with a shorter median time to complete wound closure.
3. Pressure Ulcers: A study published in the Journal of Wound Care in 2019 evaluated collagenase treatment in patients with pressure ulcers. The results showed a significant reduction in wound size and a higher proportion of wounds achieving complete healing with collagenase treatment. The study concluded that collagenase was effective in facilitating wound healing in pressure ulcers.
4. Surgical Wounds: Collagenase preparations have also been studied for their effectiveness in surgical wound healing. A randomized controlled trial published in the Annals of Plastic Surgery in 2018 compared collagenase treatment with standard care in patients with surgical wounds. The study found that collagenase treatment resulted in faster wound healing, reduced wound surface area, and improved overall wound appearance.